Identification of a novel two-partner secretion locus in 5 Moraxella catarrhalis
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Identification of a novel two-partner secretion locus in Moraxella catarrhalis.
Although Moraxella catarrhalis continues to be a significant cause of disease in both children and adults, the steps involved in pathogenesis remain poorly understood. We have identified three open reading frames in the M. catarrhalis genome that encode homologues of the two-partner secretion system (TPS). The sequenced M. catarrhalis hemagglutinin-like locus of strain 7169 has a unique gene or...
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Background: Moraxella catarrhalis is Gram negative diplococci which is a member of Neisseriacae. It was considered as a harmless commensal of the upper respiratory tract. Since 1990 its pathogenecity was established and known as a common cause of respiratory infection, particularly otitis media, sinusitis and lower respiratory tract. The aim of this research was to determine the prevalence and ...
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Two-partner secretion (TPS) systems are a family of proteins being rapidly identified and characterized in a growing number of gram-negative bacteria. TPS systems mediate the secretion of proteins, many involved in virulence traits such as hemolysis, adherence to epithelial cells, inhibition of bacterial growth, and immunomodulation of the host. A TPS system typically consists of a transporter ...
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In a study lasting over two years the frequency and sensitivity of moraxella catarrhalis causing respiratory tract infections were studied. Sputum samples from patients with lower respiratory tract infections were screened for moraxella catarrhalis. The organisms isolated identified and their sensitivity determined by simple methods which are practicable. The study shows that 22.4% of the infec...
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